Formulas you can read past the front label.
HydroSure's full formula, the reasoning behind each dose and the primary literature, set out for clinicians. A practitioner program is in development.
HydroSure, in full.
Amounts per serving as printed on the label, with no proprietary blend. The notes summarize the literature listed at the end of this page.
| Ingredient | Per serving | Role | Dose note |
|---|---|---|---|
| L-Alanine | 5 g | Behaves as a compatible osmolyte in cultured human cells under hypertonic stress (Franchi-Gazzola 2006). In normal metabolism it also carries nitrogen from muscle to the liver. | Shares the lead dose with creatine. Its osmolyte role comes mostly from cell studies, and direct performance data are sparse, so we include it for that role. |
| Creatine monohydrate | 5 g | Acted as a compatible osmolyte in cultured mouse muscle cells under hypertonic stress, measured as cell survival (Alfieri 2006). Concentrated in muscle by a dedicated transporter. | A well-studied daily amount. In a trial that opened with 25 g a day for 7 days, then 5 g a day, total body water rose without a change in its distribution between compartments (Powers 2003). Without a loading week, muscle stores rise over about 4 weeks (Hultman 1996). |
| Glycine | 4 g | Described as a compatible osmolyte mainly in invertebrates and cultured cells (Yancey 2005; Franchi-Gazzola 2006). Also an inhibitory neurotransmitter. | Included as an osmolyte. We make no separate performance claim for it. |
| Taurine | 3 g | Major intracellular osmolyte, held at high levels in muscle, heart and brain (Ripps and Shen 2012; Burg and Ferraris 2008). | Exercise outcomes across doses are mixed (Chen 2021). Included for cell-volume regulation. |
| L-Glutamine | 3 g | Osmolyte long studied for cell swelling. In cell physiology research, swelling acts as a signal toward synthesis (Lang 2011). | A supporting dose. The evidence is stronger on mechanism than on outcomes in healthy, well-fed adults. |
| Betaine | 1 g | Osmolyte and methyl donor, also called trimethylglycine (Lever and Slow 2010). | Below the roughly 2.5 g a day used in strength and power trials (Lee 2010). Included as an osmolyte and methyl donor, with no performance claim. |
- Total actives
- 21 g
- Daily Value
- Not established
- Other ingredients
- Silicon dioxide
- Directions
- Mix 2 scoops in 64 ounces of water
- Net weight
- 23.3 oz (660 g)
What we decided, and why.
Each of these choices is visible on the label.
No proprietary blend
Every active appears with its exact amount. You can check each dose against the literature yourself.
No added electrolytes
HydroSure adds no sodium, potassium or magnesium. We built it around the osmolyte side of cell water. People who sweat heavily for long periods still need electrolytes from food or a separate product.
No stimulants
There is no caffeine or other stimulant on the label.
Doses shown against the evidence
Where a dose sits below the amount used in published trials, as betaine does, we say so on the page. We do not borrow an effect from a study that used more.
One formula, two audiences.
We keep consumer education and professional information separate, and we write each one for its reader.
For everyone
Our public pages are educational, and that includes this one. They use structure and function language only, as the rules for dietary supplements require.
For practitioners
Deeper material, such as formulation monographs and literature summaries, will sit inside the practitioner program. We will write it for readers with clinical training and share it with verified professionals only.
The practitioner program.
A dedicated channel for licensed healthcare professionals. It is not open yet. We plan to include:
- Practitioner accounts with credential verification
- Professional pricing and terms, separate from consumer offers
- Product samples for evaluation
- Clinician materials, starting with formulation monographs
There is no sign-up form yet. Write to us through the contact page and tell us about your practice.
Primary literature
Cited in the formulation table. Each link opens the full text or the abstract.
- Alfieri RR, Bonelli MA, Cavazzoni A, et al. Creatine as a compatible osmolyte in muscle cells exposed to hypertonic stress. The Journal of Physiology, 2006.
- Burg MB, Ferraris JD. Intracellular organic osmolytes: function and regulation. Journal of Biological Chemistry, 2008.
- Chen Q, et al. The dose response of taurine on aerobic and strength exercises: a systematic review. Frontiers in Physiology, 2021.
- Franchi-Gazzola R, Dall'Asta V, Sala R, et al. The role of the neutral amino acid transporter SNAT2 in cell volume regulation. Acta Physiologica, 2006.
- Hultman E, Soderlund K, Timmons JA, et al. Muscle creatine loading in men. Journal of Applied Physiology, 1996.
- Lang F. Effect of cell hydration on metabolism. Nestlé Nutrition Institute Workshop Series, 2011.
- Lee EC, et al. Ergogenic effects of betaine supplementation on strength and power performance. Journal of the International Society of Sports Nutrition, 2010.
- Lever M, Slow S. The clinical significance of betaine, an osmolyte with a key role in methyl group metabolism. Clinical Biochemistry, 2010.
- Powers ME, et al. Creatine supplementation increases total body water without altering fluid distribution. Journal of Athletic Training, 2003.
- Ripps H, Shen W. Review: Taurine, a "very essential" amino acid. Molecular Vision, 2012.
- Yancey PH. Organic osmolytes as compatible, metabolic and counteracting cytoprotectants in high osmolarity and other stresses. Journal of Experimental Biology, 2005.